circRNA basic information
circBase ID: hsa_circ_0010882
Name: hsa_circ_RPL11
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: gastric cancer cell lines (HGC-27, MKN-45, SGC-7901, BGC-823), normal gastric cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: positively associated with PI3K/Akt/mTOR signaling pathway
Associated microRNA: -
Biological function: promoted proliferation, migration, and invasiveness while inhibits apoptosis
Molecular mechanism: regulation of the PI3K/Akt/mTOR signaling pathway
Survival: poor
Supported No.:
 1
Description:

Hsa_circ_0010882, as an oncogenic molecule, is highly expressed in the plasma of patients with GC and is associated with poor prognosis. It plays an important role in proliferation, migration, and invasive genotypes of GC cell lines via regulation of the PI3K/Akt/mTOR signaling pathway. Additionally, it might be a potential prognostic biomarker for GC patients.
Other information
Title:

Circular RNA hsa_circ_0010882 promotes the progression of gastric cancer via regulation of the PI3K/Akt/mTOR signaling pathway.

Journal: Eur Rev Med Pharmacol Sci
Published: 2020/2/26
PubMed ID: 32096170