circRNA basic information
circBase ID: hsa_circ_0031242
Name: hsa_circ_PRMT5
Synonym: -
Host Gene: hsa-miR-188-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human liver cell line (THLE-2), HCC cell line (SNU-387), human HCC cell line (HCCLM3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HK2
Associated microRNA: hsa-miR-188-5p
Biological function: enhances the proliferation, migration and glycolysis of hepatoma cells
Molecular mechanism: targeting hsa-miR-188-5p/HK2 axis
Survival: -
Supported No.:
 3
Description:

In summary, circ-PRMT5 might play a key role in proliferation, migration, glycolysis of HCC cells via miR-188-5p/HK2 axis, which indicated that circ-PRMT5 might be a potential therapeutic target for HCC treatment.
Other information
Title:

Circ-PRMT5 enhances the proliferation, migration and glycolysis of hepatoma cells by targeting miR-188-5p/HK2 axis.

Journal: Ann Hepatol
Published: 2020/2/25
PubMed ID: 32089501