circRNA basic information
circBase ID: -
Name: mmu_circ_Smyd4
Synonym: mm9_circ_016597
Host Gene: mmu-miR-652-3p
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: cardiovascular disease
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: MTP18
Associated microRNA: mmu-miR-652-3p
Biological function: mediates cardiomyocyte death
Molecular mechanism: targeting and downregulating mmu-miR-652-3p; this in turn blocks mitochondrial fission and cardiomyocyte cell death by suppressing MTP18 translation
Survival: -
Supported No.:
 1
Description:

A circRNA (mitochondrial fission and apoptosis-related circRNA, termed as MFACR) regulates mitochondrial fission and apoptosis in the heart by directly targeting and downregulating miR-652-3p; this in turn blocks mitochondrial fission and cardiomyocyte cell death by suppressing MTP18 translation. Our results reveal a crucial role for circRNA in regulating mitochondrial dynamics and apoptosis in the heart; as such, circRNAs may serve as a potential therapeutic avenue for cardiovascular diseases.
Other information
Title:

Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression.

Journal: Cell Death Differ
Published: 2017/5/13
PubMed ID: 28498369