circRNA basic information
circBase ID: -
Name: -
Synonym: CircRNA_002581
Host Gene: mmu-miR-122
 
 
 
Disease basic information
DO ID:
 80547
DO name: non-alcoholic steatohepatitis
Disease details: nonalcoholic steatohepatitis
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: CPEB1
Associated microRNA: mmu-miR-122
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

CPEB1-PTEN-AMPK-mTOR pathway is shown to link the autophagy and circRNA_002581 knockdown-mediated NASH alleviation. CircRNA_002581-miR-122-CPEB1 axis actively participates in the pathogenesis of NASH through PTEN-AMPK-mTOR pathway-related autophagy suppression. Targeting circRNA_002581 is a potential therapeutic strategy for NASH through partial autophagy restoration.
Other information
Title:

Antagonizing circRNA_002581-miR-122-CPEB1 axis alleviates NASH through restoring PTEN-AMPK-mTOR pathway regulated autophagy.

Journal: Cell Death Dis
Published: 2020/2/15
PubMed ID: 32054840