circRNA basic information
circBase ID: -
Name: hsa_circ_FNTA
Synonym: -
Host Gene: hsa-miR-370-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: normal human urothelial epithelial cell line (SVHUC, BCa, T24, J82, 5637, UMUC3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FNTA/KRAS
Associated microRNA: hsa-miR-370-3p
Biological function: promote bladder cancer invasion
Molecular mechanism: AR/ADAR2/circFNTA/hsa-miR-370-3p/FNTA/KRAS axis
Survival: -
Supported No.:
 1
Description:

A clinical BCa sample survey shows that circFNTA expression is elevated in BCa tissues, and results from a BCa mouse model indicate that depletion of circFNTA leads to the suppression of BCa metastases and increased cisplatin chemo-sensitivity.
Other information
Title:

Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion.

Journal: EMBO Rep
Published: 2020/2/14
PubMed ID: 32052578