circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-1207-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell lines (HT29, LOVO, SW480, PKO), normal human colon epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FMNL2
Associated microRNA: hsa-miR-1207-5p
Biological function: promote migration, invasion and proliferation
Molecular mechanism: circHIPK3/hsa-miR-1207-5p/FMNL2 axis
Survival: poor
Supported No.:
 2
Description:

circHIPK3 promoted CRC cells migration, invasion and proliferation modulating of FMNL2 by sponging of miR-1207-5p. Our findings indicated that circHIPK3/miR-1207-5p/FMNL2 axis might be a new strategy in molecular treatment of CRC.
Other information
Title:

CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal.

Journal: Biochem Biophys Res Commun
Published: 2020/2/13
PubMed ID: 32046858