circRNA basic information
circBase ID: -
Name: hsa_circ_MYLK
Synonym: -
Host Gene: hsa-miR-513a-5p
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HK_2 cell, human RCC cell lines (ACHN, 786_O, Caki_2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: VEGFC
Associated microRNA: hsa-miR-513a-5p
Biological function: promotes tumour growth and metastasis
Molecular mechanism: modulating hsa-miR-513a-5p/VEGFC signalling
Survival: poor
Supported No.:
 1
Description:

circMYLK has an oncogenic role in RCC growth and metastasis by modulating miR-513a-5p/VEGFC signalling. Thus, circMYLK has potential as a diagnostic biomarker and therapeutic target in the treatment of RCC.
Other information
Title:

Circular RNA MYLK promotes tumour growth and metastasis via modulating miR-513a-5p/VEGFC signalling in renal cell carcinoma.

Journal: J Cell Mol Med
Published: 2020/4/29
PubMed ID: 32342645