circRNA basic information
circBase ID: -
Name: hsa_circ_VAPA
Synonym: -
Host Gene: hsa-miR-125b-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SGC7901, HGC27, SGC7901/DDP
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3
Associated microRNA: hsa-miR-125b-5p
Biological function: CircVAPA depletion inhibited proliferation, migration, and invasion and increased apoptosis of GC cells.
Molecular mechanism: circVAPA was able to sponge hsa-miR-125b-5p, and hsa-miR-125b-5p could target STAT3 in the GC cells
Survival: -
Supported No.:
 1
Description:

CircVAPA promotes chemotherapy resistance and malignant progression in GC by miR-125b-5p/STAT3 signaling. Our findings present novel insights into the mechanism by which circVAPA regulates chemotherapy resistance of GC cells. CircVAPA and miR-125b-5p may be considered as the potential targets for GC therapy.
Other information
Title:

Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis.

Journal: World J Gastroenterol
Published: 2021/3/2
PubMed ID: 33642823