circRNA basic information
circBase ID: -
Name: hsa_circ_HIAT1
Synonym: -
Host Gene: hsa-miR-21
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human GC cell lines (MKN28, MKN45)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: phosphatase and tensin homolog/phosphatidylinositol 3 kinase/protein kinase B and extracellular signal-regulated kinase signal pathways
Associated microRNA: hsa-miR-21
Biological function: inhibits proliferation and epithelial-mesenchymal transition
Molecular mechanism: downregulate hsa-miR-21
Survival: -
Supported No.:
 3
Description:

circHIAT1 inhibited the activation of phosphatase and tensin homolog/phosphatidylinositol 3 kinase/protein kinase B and extracellular signal-regulated kinase signal pathways via downregulating miR-21. CircHIAT1 functioned as a tumor inhibitor in GC cells through downregulating miR-21, and could be a novel target for GC treatment.
Other information
Title:

Circular RNA circHIAT1 inhibits proliferation and epithelial-mesenchymal transition of gastric cancer cell lines through downregulation of miR-21.

Journal: J Biochem Mol Toxicol
Published: 2020/2/6
PubMed ID: 32020707