circRNA basic information
circBase ID: hsa_circ_0060060
Name: hsa_circ_EIF6
Synonym: -
Host Gene: hsa-miR-144-3p
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal thyroid cell line (HTori-3), thyroid tumor cell lines (TPC1, BHT101)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: TGF-alpha
Associated microRNA: hsa-miR-144-3p
Biological function: promote the cisplatin-resistance
Molecular mechanism: promoted autophagy by regulating hsa-miR-144-3p/TGF-alpha axis
Survival: -
Supported No.:
 1
Description:

circEIF6 promoted autophagy by regulating miR-144-3p/TGF-alpha axis, enhancing the cisplatin-resistance in PTC and ATC cells. CircEIF6 promoted tumor growth by regulating miR-144-3p/TGF-alpha and circEIF6 knock-down enhanced cisplatin sensitivity in vivo.
Other information
Title:

Circular RNA EIF6 (Hsa_circ_0060060) sponges miR-144-3p to promote the cisplatin-resistance of human thyroid carcinoma cells by autophagy regulation.

Journal: Aging (Albany NY)
Published: 2018/12/13
PubMed ID: 30540564