circRNA basic information
circBase ID: -
Name: hsa_circ_UBAP2
Synonym: -
Host Gene: hsa-miR-422a
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human ESCC cell lines (ECA-109, TE-9, TE-10, KYSE-150), human normal esophageal epithelial cell line (Het-1A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Rab10
Associated microRNA: hsa-miR-422a
Biological function: promoted the proliferation, migration and invasion
Molecular mechanism: sponging microRNA (miR)-422a, and hsa-miR-422a directly targeted Rab10
Survival: -
Supported No.:
 1
Description:

circUBAP2 exerted its role via sponging microRNA (miR)-422a, and miR-422a directly targeted Rab10 in ESCC cells. These findings suggested that circUBAP2 acted as oncogene through regulating the miR-422a/Rab10 axis in ESCC.
Other information
Title:

Knockdown of circular RNA UBAP2 inhibits the malignant behaviours of esophageal squamous cell carcinoma by microRNA-422a/Rab10 axis.

Journal: Clin Exp Pharmacol Physiol
Published: 2020/2/6
PubMed ID: 32012318