circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell lines (HCT-116, DLD-1), human normal colonic epithelium cell lines (NCM460, CCD841CoN)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EGFR and IGF-1R
Associated microRNA: hsa-miR-7
Biological function: promoted proliferation and invasion
Molecular mechanism: blocking hsa-miR-7 and positively regulating EGFR and IGF-1R
Survival: poor
Supported No.:
 2
Description:

CDR1as had a higher expression in CRC tissues compared to adjacent, normal mucosa and was positively associated with tumor size, T stage, lymph node metastasis, and poor overall survival (OS). Downregulation of CDR1as suppressed CRC cell proliferation and invasion and increased microRNA-7 (miR-7) expression. Intriguingly, ectopic expression of miR-7 in CRC cells consistently inhibited proliferation and invasion, and the miR-7 inhibitor was able to rescue the function of CDR1as knockdown.

Other information
Title:

Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7.

Journal: Onco Targets Ther
Published: 2017/4/25
PubMed ID: 28435295