circRNA basic information
circBase ID: -
Name: hsa_circ_SMG1.72
Synonym: circRNA-SMG1.72
Host Gene: hsa-miR-141-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SK-HEP-1, HEK 293T, HA22T
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Gelsolin
Associated microRNA: hsa-miR-141-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

ERalpha can suppress HCC cell invasion via altering the ERalpha/circRNA-SMG1.72/miR-141-3p/GSN signaling, and targeting this newly identified signaling with small molecules may help in the development of novel therapies to better suppress the HCC progression.
Other information
Title:

Targeting the estrogen receptor alpha (ERalpha)-mediated circ-SMG1.72/miR-141-3p/Gelsolin signaling to better suppress the HCC cell invasion.

Journal: Oncogene
Published: 2020/1/31
PubMed ID: 31996784