circRNA basic information
circBase ID: -
Name: hsa_circ_MAPK4
Synonym: -
Host Gene: hsa-miR-125a-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: glioma cell lines (U138, U373, U87)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: p38/MAPK signaling pathway
Associated microRNA: hsa-miR-125a-3p
Biological function: promoted the survival and inhibited the apoptosis of glioma cells
Molecular mechanism: sponging hsa-miR-125a-3p
Survival: poor
Supported No.:
 2
Description:

circ-MAPK4 is a critical player in glioma cell survival and apoptosis via p38/MAPK signaling pathway through modulation of miR-125a-3p, which can serve as a new therapeutic target for treatment of gliomas.
Other information
Title:

Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas.

Journal: Mol Cancer
Published: 2020/1/30
PubMed ID: 31992303