circRNA basic information
circBase ID: -
Name: hsa_circ_SMAD4
Synonym: circSMAD4
Host Gene: hsa-miR-377-3p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: Diabetic nephropathy
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: SV40-MES13
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: BMP7
Associated microRNA: hsa-miR-377-3p
Biological function: CircSMAD4 overexpression alleviated, while circSMAD4 knockdown aggravated HG-induced SV40-MES13 cell injuries.
Molecular mechanism: _iR-377-3p was targeted by circSMAD4, and miR-377-3p enrichment partly reversed the effects of circSMAD4 overexpression.
Survival: -
Supported No.:
 1
Description:

CircSMAD4 alleviates HG-induced SV40-MES13 cell inflammation, ECM deposition and apoptosis by relieving miR-377-3p-mediated inhibition on BMP7 in DN progression.
Other information
Title:

CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition.

Journal: Diabetol Metab Syndr
Published: 2021/11/22
PubMed ID: 34801077