circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: cell line
Sample type details: SJSA-1, U2OS
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EGFR
Associated microRNA: hsa-miR-7
Biological function: Promotes Osteosarcoma Migration and Invasion
Molecular mechanism: enhance epidermal growth factor receptor (EGFR) expression by reducing the level of hsa-miR-7
Survival: -
Supported No.:
 2
Description:

our research uncovered an important role of the cir-ITCH/miR-7/EGFR pathway in the migration and invasion of osteosarcoma cells and suggested that cir-ITCH may be a prognostic marker and a promising therapeutic target for osteosarcoma.
Other information
Title:

Circular RNA cir-ITCH Promotes Osteosarcoma Migration and Invasion through cir-ITCH/miR-7/EGFR Pathway.

Journal: Technol Cancer Res Treat
Published: 2020/1/22
PubMed ID: 31960764