circRNA basic information
circBase ID: hsa_circ_0000396
Name: -
Synonym: Circ_0000396
Host Gene: hsa-miR-574-5p
 
 
 
Disease basic information
DO ID:
 7148
DO name: rheumatoid arthritis
Disease details: rheumatoid arthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Human RASFs were isolated from synovial tissues
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: RSPO1
Associated microRNA: hsa-miR-574-5p
Biological function: Circ_0000396 overexpression suppressed the proliferation and inflammatory response and triggered the apoptosis of RA synovial fibroblasts (RASFs), accompanied by decreases in PCNA, Cyclin D1, Cyclin E1, Bcl2, IL-1beta and TNF-¦Á protein expression and an increase in Bax protein expression.
Molecular mechanism: Circ_0000396 could up-regulate the expression of RSPO1 by sponging miR-574-5p in RASFs. RSPO1 interference largely overturned circ_0000396 overexpression-mediated effects in RASFs.
Survival: -
Supported No.:
 2
Description:

Circ_0000396 restrained the proliferation and inflammation and induced the apoptosis of RASFs by mediating miR-574-5p/RSPO1 axis, which provided novel potential targets for RA treatment.
Other information
Title:

Circ_0000396 suppresses the proliferation and inflammation of rheumatoid arthritis synovial fibroblasts by targeting miR-574-5p/RSPO1 axis.

Journal: J Orthop Surg Res
Published: 2023/9/22
PubMed ID: 37737195