circRNA basic information
circBase ID: -
Name: hsa_circ_LAS1L
Synonym: -
Host Gene: hsa-miR-125b
 
 
 
Disease basic information
DO ID:
 9408
DO name: acute myocardial infarction
Disease details: acute myocardial Infarction
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CFs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SFRP5
Associated microRNA: hsa-miR-125b
Biological function: inhibiting the activation, proliferation and migration of CF, and promoting apoptosis
Molecular mechanism: bind directly to hsa-miR-125b
Survival: -
Supported No.:
 1
Description:

This suggests that circ_LAS1L/miR-125b/SFRP5 pathway can regulate the biological function of CF and may play an important role in the process of myocardial fibrosis, thus providing an important theoretical basis for the regulation of myocardial fibrosis after myocardial infarction.
Other information
Title:

Circ_LAS1L regulates cardiac fibroblast activation, growth, and migration through miR-125b/SFRP5 pathway.

Journal: Cell Biochem Funct
Published: 2020/1/18
PubMed ID: 31950540