circRNA basic information
circBase ID: hsa_circ_0005986
Name: hsa_circ_PRDM2
Synonym: -
Host Gene: hsa-miR-129-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (HepG2, SMCC7721, Huh7), human normal hepatic cell line (L02)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: NOTCH1
Associated microRNA: hsa-miR-129-5p
Biological function: suppress cell proliferation, migration, and invasion
Molecular mechanism: hsa_circ_0005986 downregulation liberated hsa-miR-129-5p and decreased the expression level of Notch1mRNA
Survival: better
Supported No.:
 2
Description:

Hsa_circ_0005986 downregulation liberated miR-129-5p and decreased the expression level of Notch1mRNA. hsa_circ_0005986 downregulation accelerated cell proliferation by promoting the G0/G1 to S phase transition.
Other information
Title:

Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma.

Journal: Oncotarget
Published: 2017/4/15
PubMed ID: 28410211