circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lung cancer cell lines (A549, Calu_3, CAEP, SK_MES_1), human bronchial epithelioid cells (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promote cell viability, migration and invasion and suppress apoptosis
Molecular mechanism: upregulating hsa-miR-219a-5p and downregulating SOX5
Survival: -
Supported No.:
 5
Description:

Knockdown of circCDR1as inhibited the progression of NSCLC by decreasing cell viability, migration and invasion and increasing apoptosis by upregulating miR-219a-5p and downregulating SOX5.
Other information
Title:

CircRNA CDR1as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p/SOX5 axis.

Journal: Thorac Cancer
Published: 2020/1/10
PubMed ID: 31917898