circRNA basic information
circBase ID: -
Name: hsa_circ_SOX4
Synonym: circ-SOX4
Host Gene: hsa-miR-1270
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: LUAD cell lines (A549, SPC-A1, H1299, PC-9), normal human lung epithelial cell line (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PLAGL2
Associated microRNA: hsa-miR-1270
Biological function: promote cell proliferation, invasion and migration
Molecular mechanism: sponging hsa-miR-1270 and modulating PLAGL2
Survival: -
Supported No.:
 1
Description:

Circ-SOX4 boosted the development of LUAD and activate WNT signaling pathway through sponging miR-1270 and modulating PLAGL2, which provided a valuable theoretical basis for exploring underlying therapeutic target in LUAD.
Other information
Title:

Circ-SOX4 drives the tumorigenesis and development of lung adenocarcinoma via sponging miR-1270 and modulating PLAGL2 to activate WNT signaling pathway.

Journal: Cancer Cell Int
Published: 2020/1/9
PubMed ID: 31911754