circRNA basic information
circBase ID: hsa_circ_0001667
Name: hsa_circ_HEATR2
Synonym: -
Host Gene: hsa-miR-125a-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human breast cancer (MDA-MB-468, MCF-7, T4TD, BT459, MDA-MB-435), normal human breast epithelial cells (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TAZ
Associated microRNA: hsa-miR-125a-5p
Biological function: proliferation (+)
Molecular mechanism: circ_0001667 negatively regulated hsa-miR-125a-5p expression leading to promoting TAZ expression through Hippo signal pathway in breast cancer cells
Survival: poor
Supported No.:
 4
Description:

This study uncovered that circ_0001667 was a potential breast cancer prognostic marker, as well as a potential therapeutic target to inhibit breast cancer metastasis by circ_0001667/miR-125a-5p/TAZ axis.
Other information
Title:

Circ_0001667 promotes breast cancer cell proliferation and survival via Hippo signal pathway by regulating TAZ.

Journal: Cell Biosci
Published: 2020/1/2
PubMed ID: 31893023