circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human pulmonary alveolar epithelial cells (PAEC), human LUAD cell lines (PC9, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EGFR, PI3K
Associated microRNA: -
Biological function: contributes to pemetrexed and cisplatin chemoresistance
Molecular mechanism: -
Survival: -
Supported No.:
 2
Description:

the CDR1-AS is high-expressed in LUAD and is an independent prognostic biomarker for LUAD patients. The high-expression of CDR1-AS is related with the PTX and CDDP insensitivity of LUAD patients, CDR1-AS promotes PTX and CDDP chemoresistance through EGFR/PI3K signaling pathway in LUAD.
Other information
Title:

Circular RNA CDR1-AS contributes to pemetrexed and cisplatin chemoresistance through EGFR/PI3K signaling pathway in lung adenocarcinoma.

Journal: Biomed Pharmacother
Published: 2019/12/28
PubMed ID: 31881486