circRNA basic information
circBase ID: hsa_circ_0037251
Name: hsa_circ_METRN
Synonym: -
Host Gene: hsa-miR-1229-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human glioma cell lines (U373, U251), human embryonic kidney (HEK) 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: mTOR
Associated microRNA: hsa-miR-1229-3p
Biological function: promoted cell proliferation, invasion and migration
Molecular mechanism: inhibited the expression of hsa-miR-1229-3p and up-regulated the expression of mTOR
Survival: -
Supported No.:
 1
Description:

These results indicated that hsa_circ_0037251 may act as a tumour promoter by a hsa_circ_0037251/miR-1229-3p/mTOR axis, and these potential biomarkers may be therapeutic targets for glioma.
Other information
Title:

Circular METRN RNA hsa_circ_0037251 Promotes Glioma Progression by Sponging miR-1229-3p and Regulating mTOR Expression.

Journal: Sci Rep
Published: 2019/12/26
PubMed ID: 31875034