circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 10652
DO name: Alzheimer disease
Disease details: Alzheimer disease
Species: human
Species details: human
Sample type: cell line
Sample type details: HEK293T, SH-SY5Y cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: NF-kappaB, UCHL1, APP and BACE1
Associated microRNA: hsa-miR-7
Biological function: -
Molecular mechanism: inhibits translation of NF-kappaB and induces its cytoplasmic localization, thus derepressing expression of UCHL1, which promotes APP and BACE1 degradation
Survival: -
Supported No.:
 1
Description:

ciRS-7 expression inhibits translation of NF-kappaB and induces its cytoplasmic localization, thus derepressing expression of UCHL1, which promotes APP and BACE1 degradation.
Other information
Title:

The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF-kappaB-dependent manner.

Journal: FEBS J
Published: 2017/3/16
PubMed ID: 28296235