circRNA basic information
circBase ID: hsa_circ_0000267
Name: -
Synonym: circ_0000267
Host Gene: hsa-miR-503-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal gastric mucosal epithelial cell line (GES_1), human gastric cancer cell lines (MGC_803, MKN_45, NUGC_3, SGC_7901, BGC823, MKN_28 )
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA2
Associated microRNA: hsa-miR-503-5p
Biological function: accelerated GC cell proliferation, metastasis, and EMT processes
Molecular mechanism: adsorbing hsa-miR-503-5p and upregulating HMGA2 expression
Survival: poor
Supported No.:
 1
Description:

Circ_0000267 is an oncogenic circRNA that affects the progression of GC, which participates in promotion of GC proliferation, migration, invasion, and EMT via modulating the miR-503-5p/HMGA2 axis.
Other information
Title:

Circ_0000267 promotes gastric cancer progression via sponging MiR-503-5p and regulating HMGA2 expression.

Journal: Mol Genet Genomic Med
Published: 2019/12/18
PubMed ID: 31845519