circRNA basic information
circBase ID: hsa_circ_0001742
Name: -
Synonym: circ_0001742
Host Gene: hsa-miR-431-5p
 
 
 
Disease basic information
DO ID:
 50865
DO name: tongue squamous cell carcinoma
Disease details: tongue squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human oral keratinocytes cell line (HOK), human TSCC cell lines (CAL27, SCC4)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ATF3
Associated microRNA: hsa-miR-431-5p
Biological function: promote proliferation, migration, invasion and EMT and supresse apoptosis
Molecular mechanism: regulated ATF3 expression through hsa-miR-431-5p
Survival: -
Supported No.:
 4
Description:

Our results demonstrated that circ_0001742 plays a tumor-promoting effect in TSCC cells by serving as a competing endogenous RNA (ceRNA) to regulate miR-431-5p/ATF3 axis, which might provide a potential therapeutic target for TSCC.
Other information
Title:

Circ_0001742 promotes tongue squamous cell carcinoma progression via miR-431-5p/ATF3 axis.

Journal: Eur Rev Med Pharmacol Sci
Published: 2019/12/17
PubMed ID: 31841185