circRNA basic information
circBase ID: -
Name: hsa_circ_ASAP1
Synonym: -
Host Gene: hsa-miR-326, hsa-miR-532-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human liver cancer cell lines (MHCC97L, MHCC97H, HCCLM3), normal liver cell line (L0-2), non-metastatic human HCC cell lines (HepG2, PLC/PRF/5)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: CSF-1
Associated microRNA: hsa-miR-326, hsa-miR-532-5p
Biological function: promoted cell proliferation, colony formation, migration, and invasion
Molecular mechanism: acts as a competing endogenous RNA for microRNA 326 (hsa-miR-326) and microRNA 532-5p (hsa-miR-532-5p)
Survival: poor
Supported No.:
 3
Description:

We identified circASAP1 as a key regulator of HCC metastasis that acts on miR-326/miR-532-5p-MAPK1/CSF-1 signaling and serves as a prognostic predictor in patients with HCC.
Other information
Title:

Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis.

Journal: Hepatology
Published: 2019/12/16
PubMed ID: 31838741