circRNA basic information
circBase ID: -
Name: hsa_circ_FGFR1
Synonym: -
Host Gene: hsa-miR-381-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (NCI-H358, NCI-H1299, A549, HCC827, NCI-H1650, NCI-H838, NCI-H292), LLC mouse lung cancer cell line (HEK-293_T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-381-3p
Biological function: promoted the migration, invasion, proliferation, and immune evasion
Molecular mechanism: circFGFR1 could directly interact with hsa-miR-381-3p and subsequently act as a miRNA sponge to upregulate the expression of the hsa-miR-381-3p target gene C-X-C motif chemokine receptor 4 (CXCR4),
Survival: poor
Supported No.:
 1
Description:

our results suggest the critical role of circFGFR1 in the proliferation, migration, invasion, and immune evasion abilities of NSCLC cells and provide a new perspective on circRNAs during NSCLC progression.
Other information
Title:

Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells.

Journal: Mol Cancer
Published: 2019/12/10
PubMed ID: 31815619