circRNA basic information
circBase ID: hsa_circ_0001490
Name: -
Synonym: circ_0001490
Host Gene: hsa-miR-579-3p
 
 
 
Disease basic information
DO ID:
 399
DO name: tuberculosis
Disease details: tuberculosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: THP-1 macrophages
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: FSTL1
Associated microRNA: hsa-miR-579-3p
Biological function: Circ_0001490 overexpression suppressed M.tb survival and promoted the viability and inflammatory response of THP-1 macrophages.
Molecular mechanism: _irc_0001490 interacted with microRNA-579-3p (miR-579-3p), and circ_0001490 overexpression-induced protective effects in M.tb-infected THP-1 macrophages were largely overturned by the overexpression of miR-579-3p.
Survival: -
Supported No.:
 1
Description:

In conclusion, our results demonstrated that circ_0001490 suppressed M.tb survival and promoted the viability and inflammatory response of M.tb-infected THP-1 macrophages partly by regulating miR-579-3p/FSTL1 axis.
Other information
Title:

Circ_0001490/miR-579-3p/FSTL1 axis modulates the survival of mycobacteria and the viability, apoptosis and inflammatory response in Mycobacterium tuberculosis-infected macrophages.

Journal: Tuberculosis (Edinb)
Published: 2021/9/24
PubMed ID: 34555658