circRNA basic information
circBase ID: -
Name: hsa_circ_MLLT10
Synonym: -
Host Gene: hsa-miR-509-3-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human gastric cancer cell lines (HGC-27, MKN-28, MKN-45, MGC-803, BGC-823, AGS, SGC-7901), 293T cells
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
UP
Associated gene: GINS4
Associated microRNA: hsa-miR-509-3-5p
Biological function: promotes gastric cancer growth and progression
Molecular mechanism: activating Rac1 and CDC42
Survival: poor
Supported No.:
 1
Description:

circMLLT10 acts as a miR-509-3-5p sponge to attenuate its repressive effect on target GINS4.
Other information
Title:

The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42.

Journal: Theranostics
Published: 2019/11/23
PubMed ID: 31754397