circRNA basic information
circBase ID: hsa_circ_0001178
Name: hsa_circ_USP25
Synonym: -
Host Gene: hsa-miR-382, hsa-miR-587, hsa-miR-616
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CRC cells (HCT116, HT29, HCT8, SW480, LoVo, SW620), noncancerous colon cell (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZEB1
Associated microRNA: hsa-miR-382, hsa-miR-587, hsa-miR-616
Biological function: promote migratory and invasive capabilities
Molecular mechanism: acted as a competing endogenous RNA (ceRNA) for hsa-miR-382/587/616 to upregulate ZEB1
Survival: poor
Supported No.:
 3
Description:

our data uncover the crucial role of hsa_circ_0001178 in CRC metastasis, and targeted therapy based on this positive feedback ceRNA axis may be a promising treatment for metastatic CRC patients.
Other information
Title:

Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs.

Journal: Biol Chem
Published: 2019/11/21
PubMed ID: 31747371