circRNA basic information
circBase ID: hsa_circ_0014188
Name: hsa_circ_SNX27
Synonym: circ-SNX27
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (Hep 3B, Huh7, MHCC-97H, SNU-182), human normal liver cells (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RPN1
Associated microRNA: hsa-miR-375
Biological function: Knocking-down circ-SNX27 in HCC cells abated their proliferative and invasive abilities but raised their caspase-3 activity. Moreover, the poor levels of circ-SNX27 inhibited HCC tumor growth among the mice.
Molecular mechanism: circ-SNX27/hsa-miR-375/RPN1 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

This research demonstrated that circ-SNX27 accelerated the progression of HCC by modulating the miR-375/RPN1 axis. This is indicative of circ-SNX27s potential as a target for the treatment of HCC.
Other information
Title:

Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression.

Journal: Korean J Physiol Pharmacol
Published: 2023/6/30
PubMed ID: 37386831