circRNA basic information
circBase ID: hsa_circ_0001361
Name: -
Synonym: circ0001361
Host Gene: hsa-miR-491-5p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human BC cell lines (EJ, UMUC3, RT4, 5637), human immortalized uroepithelium cell line (SV-HUC-1)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: MMP9
Associated microRNA: hsa-miR-491-5p
Biological function: promotes bladder cancer invasion and metastasis
Molecular mechanism: directly interact with hsa-miR-491-5p to upregulate MMP9 expression
Survival: -
Supported No.:
 2
Description:

circ0001361 plays oncogenic role in BC invasion and metastasis through targeting the miR-491-5p/MMP9 axis, and it might be a potential novel target for BC therapy.
Other information
Title:

Hsa_circ_0001361 promotes bladder cancer invasion and metastasis through miR-491-5p/MMP9 axis.

Journal: Oncogene
Published: 2019/11/11
PubMed ID: 31705065