circRNA basic information
circBase ID: -
Name: -
Synonym: circ_0074027
Host Gene: hsa-miR-185-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cells (H358, H1299, H1581, A549), 16HBE
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BRD4, MADD
Associated microRNA: hsa-miR-185-3p
Biological function: increased cell proliferation, migration and invasion, and inhibited cell apoptosis
Molecular mechanism: circ_0074027 directly sponges hsa-miR-185-3p to enhance bromodomain-containing protein 4 (BRD4) and MAPK-activating death domain-containing protein (MADD) expression levels at the posttranscriptional level.
Survival: -
Supported No.:
 2
Description:

upregulated circ_0074027 in NSCLC accelerates cell progression via miR-185-3p/BRD4/MADD pathway as a competing endogenous RNA.
Other information
Title:

Circular RNA circ_0074027 indicates a poor prognosis for NSCLC patients and modulates cell proliferation, apoptosis, and invasion via miR-185-3p mediated BRD4/MADD activation.

Journal: J Cell Biochem
Published: 2019/11/5
PubMed ID: 31680319