circRNA basic information
circBase ID: hsa_circ_0001387
Name: hsa_circ_WHSC1
Synonym: CircWHSC1
Host Gene: hsa-miR-145, hsa-miR-1182
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MUC1, hTERT
Associated microRNA: hsa-miR-145, hsa-miR-1182
Biological function: increased cell proliferation, migration and invasion, and inhibited cell apoptosis
Molecular mechanism: circWHSC1 could sponge hsa-miR-145 and hsa-miR-1182 and up-regulate the expression of downstream targets MUC1 and hTERT.
Survival: -
Supported No.:
 1
Description:

the highly expressed circWHSC1 in ovarian cancer promotes tumorigenesis by sponging miR-145 and miR-1182, and its exosome forms induce tumor metastasis through acting on peritoneal mesothelium.
Other information
Title:

CircWHSC1 promotes ovarian cancer progression by regulating MUC1 and hTERT through sponging miR-145 and miR-1182.

Journal: J Exp Clin Cancer Res
Published: 2019/11/2
PubMed ID: 31666098