circRNA basic information
circBase ID: -
Name: hsa_circ_PICALM
Synonym: -
Host Gene: hsa-miR-1265
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1265
Biological function: inhibit bladder cancer metastasis
Molecular mechanism: CircPICALM colocalized with hsa-miR-1265 and acted as a sponge for this miRNA, and the pro-invasion effect of hsa-miR-1265 was abolished by circPICALM overexpression. STEAP4, a target of hsa-miR-1265, suppressed metastasis, it bound to FAK to prevent autophosphorylation at Y397 and influenced EMT in BC cells.
Survival: better
Supported No.:
 1
Description:

CircPICALM can inhibit BC metastasis and bind to miR-1265 to block its pro-invasion activity.
Other information
Title:

Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation.

Journal: EBioMedicine
Published: 2019/10/28
PubMed ID: 31648990