circRNA basic information
circBase ID: -
Name: hsa_circ_NFATC3
Synonym: circNFATC3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GC cell lines (SGC7901, BGC823, HGC-27)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF2BP3, TRIM25
Associated microRNA: -
Biological function: the proliferation of GC cells decreased significantly after circNFATC3 knockdown in vivo and in vitro
Molecular mechanism: circNFATC3/IGF2BP3/TRIM25 axis
Survival: -
Supported No.:
 1
Description:

Our findings demonstrate that circNFATC3 promotes GC proliferation by stabilizing IGF2BP3 protein to enhance CCND1 mRNA stability.
Other information
Title:

CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability.

Journal: J Transl Med
Published: 2023/6/21
PubMed ID: 37340423