circRNA basic information
circBase ID: hsa_circ_0127621
Name: hsa_circ_APC
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0050745
DO name: diffuse large B-cell lymphoma
Disease details: diffuse large b-cell lymphoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human DLBCL cell lines (SUDHL-3, U2932, TMD8, OCI-Ly3, L428), normal human B lymphocytes (GM12878)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: inhibits the proliferation
Molecular mechanism: inactivating Wnt/beta-catenin signaling via interacting with TET1 and hsa-miR-888.
Survival: -
Supported No.:
 1
Description:

circ-APC is a novel proliferation inhibitor, and that restoring circ-APC expression may be a promising therapeutic approach for DLBCL patients.
Other information
Title:

A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/beta-catenin signaling via interacting with TET1 and miR-888.

Journal: Aging (Albany NY)
Published: 2019/10/22
PubMed ID: 31631067