circRNA basic information
circBase ID: -
Name: mmu_circ_Prkcsh
Synonym: circPrkcsh
Host Gene: mmu-miR-488
 
 
 
Disease basic information
DO ID:
 13743
DO name: spinal cord lipoma
Disease details: Spinal cord injury
Species: mouse
Species details: mouse
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: MEKK1
Associated microRNA: mmu-miR-488
Biological function: Gain- or loss-of-function experiments and in vivo assays further indicated that circPrkcsh promotes microglia M1 polarization both in vivo and in vitro.
Molecular mechanism: circPrkcsh serves as a competing endogenous RNA (ceRNA) to promote the expression of MEKK1 mRNA by sponging miR-488.
Survival: -
Supported No.:
 2
Description:

Our research provides a better understanding of the mechanism of circPrkcsh in SCI and demonstrates that the circPrkcsh/miR-488/Mekk1 axis is a promising regulatory method for the treatment of SCI.
Other information
Title:

CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway.

Journal: FASEB J
Published: 2021/11/10
PubMed ID: 34751973