circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: -
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Tca-8113, SCC-15, HOK
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT/ERK(_)/mTOR
Associated microRNA: -
Biological function: promote autophagy
Molecular mechanism: AKTsignaling pathway (+), ERK signaling pathway (+), mTOR signaling pathway (+)
Survival: poor
Supported No.:
 1
Description:

high expression of circCDR1as enhanced the viability of OSCC cells under a hypoxic microenvironment by promoting autophagy.
Other information
Title:

CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK((1/2))/mTOR signaling pathways in oral squamous cell carcinomas.

Journal: Cell Death Dis
Published: 2019/10/5
PubMed ID: 31582727