circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal hepatocytes (L-02), gastric cancer cell lines (MGC803, BGC-823, SGC7901), HEK-293 T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DS
Associated gene: REGgamma
Associated microRNA: hsa-miR-7-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 2
Description:

knock-down of CircRNA CDR1as specifically promoted the cytotoxic effects of low-dose DB on GC cells instead of hepatocytes by regulating miR-7-5p/REGgamma axis.
Other information
Title:

Downregulation of CircRNA CDR1as specifically triggered low-dose Diosbulbin-B induced gastric cancer cell death by regulating miR-7-5p/REGgamma axis.

Journal: Biomed Pharmacother
Published: 2019/9/23
PubMed ID: 31542615