circRNA basic information
circBase ID: -
Name: hsa_circ_PRMT5
Synonym: circPRMT5
Host Gene: hsa-miR-377, hsa-miR-382, hsa-miR-498
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human bronchial epithelial cell line, NSCLC cell lines (A549, 95-D, HCC827, H1299, SK-MES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EZH2
Associated microRNA: hsa-miR-377, hsa-miR-382, hsa-miR-498
Biological function: facilitates non-small cell lung cancer proliferation
Molecular mechanism: upregulating EZH2 via sponging hsa-miR-377/382/498.
Survival: -
Supported No.:
 3
Description:

circ-PRMT5 is an oncogenic circRNA in NSCLC that can promote the growth of NSCLC via regulation of miR-377/382/498-EZH2 axis.
Other information
Title:

Circular RNA circ-PRMT5 facilitates non-small cell lung cancer proliferation through upregulating EZH2 via sponging miR-377/382/498.

Journal: Gene
Published: 2019/9/4
PubMed ID: 31479715