circRNA basic information
circBase ID:
-
Name:
hsa_circ_SCAF11
Synonym:
-
Host Gene:
hsa-miR-421
Disease basic information
DO ID:
0060108
DO name:
brain glioma
Disease details:
glioma
Species:
human
Species details:
human
Sample type:
tissue, cell line
Sample type details:
human glioma cell lines (A172, U251, U87, SHG44), normal human astrocytes (NHAs)
circRNA-disease information
Detected method:
Q
Detected method confidence
High
Expression pattern:
UP
Associated gene:
SP1
,
VEGFA
Associated microRNA:
hsa-miR-421
Biological function:
promote proliferation, invasion, and tumor growth
Molecular mechanism:
circSCAF11 positively regulated the SP1 expression through sponging hsa-miR-421. Moreover, transcription factor SP1 activated the transcription of VEGFA, constructing the circSCAF11/hsa-miR-421/SP1/VEGFA axis in the glioma genesis
Survival:
poor
Supported No.:
2
Description:
Circular RNA circSCAF11 Accelerates the Glioma Tumorigenesis through the miR-421/SP1/VEGFA Axis.
Other information
Title:
Circular RNA circSCAF11 Accelerates the Glioma Tumorigenesis through the miR-421/SP1/VEGFA Axis.
Journal:
Mol Ther Nucleic Acids
Published:
2019/8/11
PubMed ID:
31400609