circRNA basic information
circBase ID: -
Name: hsa_circ_PTPRZ1
Synonym: circPTPRZ1
Host Gene: hsa-miR-1261
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: cell line
Sample type details: human glioblastoma cell lines (A172, LN229)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PAK1
Associated microRNA: hsa-miR-1261
Biological function: enhanced cell proliferation and invasion, and inhibited cell apoptosis
Molecular mechanism: circ-PTPRZ1 could promote p-PAK1 expression, while hsa-miR-1261 suppressed the activation of PAK1 by regulating the expression of circ-PTPRZ1.
Survival: -
Supported No.:
 1
Description:

in glioma cells, the expression of circ-PTPRZ1/PAK1 is regulated by miR-1261, which affects the proliferation, apoptosis, and invasion.
Other information
Title:

MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion.

Journal: Hum Cell
Published: 2019/8/1
PubMed ID: 31364003