circRNA basic information
circBase ID: -
Name: hsa_circ_TRNC18
Synonym: -
Host Gene: hsa-miR-762
 
 
 
Disease basic information
DO ID:
 10591
DO name: pre-eclampsia
Disease details: preeclampsia
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Grhl2
Associated microRNA: hsa-miR-762
Biological function: inhibits trophoblast cell migration and epithelial-mesenchymal transition
Molecular mechanism: sponged hsa-miR-762 contributed to inhibit hsa-miR-762 activity and elevated EMT-related transcriptional factor Grhl2 protein level
Survival: -
Supported No.:
 1
Description:

circTNRC18/miR-762/Grhl2 axis plays a key role in trophoblast cell migration and EMT. circTNRC18/miR-762/Grhl2 axis may be a potential therapeutic target in PE.
Other information
Title:

CircTRNC18 inhibits trophoblast cell migration and epithelial-mesenchymal transition by regulating miR-762/Grhl2 pathway in pre-eclampsia.

Journal: RNA Biol
Published: 2019/7/30
PubMed ID: 31354028