circRNA basic information
circBase ID: -
Name: hsa_circ_TP63
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXM1
Associated microRNA: -
Biological function: promotes proliferation
Molecular mechanism: circTP63 shares miRNA response elements with FOXM1. circTP63 competitively binds to hsa-miR-873-3p and prevents hsa-miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression
Survival: poor
Supported No.:
 1
Description:

circTP63 competitively binds to miR-873-3p and prevents miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression.
Other information
Title:

circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1.

Journal: Nat Commun
Published: 2019/7/22
PubMed ID: 31324812