circRNA basic information
circBase ID: -
Name: hsa_circ_ZKSCAN1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SMMC7721, HCC-LM3
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DN
Associated gene: FMRP, CCAR1
Associated microRNA: -
Biological function: negatively regulate cancer stem cells
Molecular mechanism: circZKSCAN1 exerted its inhibitive role by competitively binding FMRP, therefore, block the binding between FMRP and beta-catenin-binding protein-cell cycle and apoptosis regulator 1 (CCAR1) mRNA, and subsequently restrain the transcriptional activity of Wnt signaling
Survival: -
Supported No.:
 3
Description:

this study revealed the mechanisms underlying the regulatory role of circZKSCAN1 in HCC CSCs and identified the newly discovered Qki5-circZKSCAN1-FMRP-CCAR1-Wnt signaling axis as a potentially important therapeutic target for HCC treatment.
Other information
Title:

Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma.

Journal: Theranostics
Published: 2019/7/10
PubMed ID: 31281495