circRNA basic information
circBase ID: -
Name: hsa_circ_NOTCH1
Synonym: -
Host Gene: hsa-miR-637
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human gastric epithelial cell line (GES-1), GC cell lines (BGC-823, MGC-803, HGC-27, MKN-45, AGS, SGC-7901)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Apelin
Associated microRNA: hsa-miR-637
Biological function: enhances cell proliferation and invasiveness, and reduces cell apoptosis
Molecular mechanism: circ-NOTCH1 inhibits the transcriptional activity of hsa-miR-637, thereby upregulating the expression of its target gene Apelin and regulating cell proliferation, apoptosis, and invasiveness
Survival: -
Supported No.:
 3
Description:

in GC cells, circ-NOTCH1 inhibits the transcriptional activity of miR-637, thereby upregulating the expression of its target gene Apelin and regulating cell proliferation, apoptosis, and invasiveness.
Other information
Title:

circ-NOTCH1 acts as a sponge of miR-637 and affects the expression of its target gene Apelin to regulate gastric cancer cell growth.

Journal: Biochem Cell Biol
Published: 2019/7/6
PubMed ID: 31276627