circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCT-116, HT-29 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EGFR, RAF1
Associated microRNA: hsa-miR-7
Biological function: promotes cell proliferation, migration, and invasion
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 2
Description:

Functional assays identified overexpression of ciRS-7 in HCT116 and HT29 cells led to blocking of tumor suppressive effects of miR-7 and resulted in a more aggressive oncogenic phenotype, which was subsequently validated in cell lines and a xenograft animal model.
Other information
Title:

Circular RNA ciRS-7-A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer.

Journal: Clin Cancer Res
Published: 2017/2/9
PubMed ID: 28174233